Khảo sát khả năng hạ glucose huyết của lá Xuân hoa răng (Pseuderanthemum crenulatum) trên mô hình chuột đái tháo đường bằng alloxan

Abstract

In this study, the hypoglycaemic effects of ethanol extracts from Pseuderanthemum crenulatum leaves were investigated. The evaluated trials included: in vitro α-glucosidase inhibitory activity; oral glucose tolerance test in normoglycemic mice; hypoglycemia in an alloxan- induced diabetic mice model, and oral toxicity assay. The results showed that the ethanol extract of P. crenulatum leaves was able to inhibit α-glucosidase enzyme at IC50=66.01 µg/ml, 1.8 times higher than acarbose control (IC50 was 122.2 µg/ml). After 21 days of using leaf extract of P. crenulatum (1 g/kg) to treat diabetic mice, the blood glucose was reduced by 42.02%. This result was equivalent to gliclazide (10 mg/kg) which reduced the blood glucose of diabetic mice by 41.78%. The oral toxicity test results at a dose of 5 g/kg equivalent to 357 g of fresh leaf/kg after 72 hours was not exhibited acute oral toxicity in mice. In summary, there is a need for more studies on the ability of P. crenulatum leaves to treat diabetes.